Evaluation of Effect of Seed Cycling on Menstrual Irregularity Among Women

Authors

  • Amna Rana Department of Clinical Nutrition, Nur International University, Lahore, Pakistan. Author
  • Wisha Waheed Department of Clinical Nutrition, Nur International University, Lahore, Pakistan. Author
  • Alghayia Tahir Department of Clinical Nutrition, Nur International University, Lahore, Pakistan. Author

Keywords:

Abdominal discomfort, Blood clot, Regularity of menstruation, Seed cycle

Abstract

Background & Aims: Various seeds have gained therapeutic importance in the treatment of menstrual dysfunction, as an alternative to medicine. The study objective is to evaluate the effect of seed cycling on menstrual irregularity among women. Menstrual irregularity may affect body weight, menstrual cramps & bloating, and blood clots during the cycle. Seed cycling includes the consumption of flax seeds & pumpkin seeds during the follicular phase while sunflower seeds & sesame seeds are consumed in the luteal phase of menstruation. 

Methodology: The study sample size was 79 females aged 18 to 35 years old, practicing seed cycling. A self-structured questionnaire was used for an observational study design with a convenient sampling technique. It includes questions about anthropometrics, menstrual flow & occurrence, frequency & quantity of seeds consumed as well as its effect on menstrual cramps & bloating, blood clots, and regularity of menstruation.

Results: A total of n=79 participated in the study about 92.4% of them had noticed a change in their menstrual cycle irregularity after consuming seeds. A healthy weight was maintained among 81% of participants, 82.3% had relief from bloating & cramps, and 82.3% had improvement in blood clots during menstruation after seed cycling. Meanwhile, 7.6% of them did not affect their menstrual cycle regularity after consuming seeds.

Conclusion: Participants who had done seed cycling for a certain period maintained their menstrual cycle regularity, had relief from abdominal discomfort, sustained a healthy body weight, and aided in improvement in blood clots during the cycle.

References

Al-kadhi, N. A., Abass, K. S., & Jaafar, S. E. (2020). Enhancement effect of sesame seeds oil on some physiological parameters in the serum of female mice treated with tamoxifen. EurAsian Journal of BioSciences, 14(2), 3669-3681.

Aslam, M., Shauket, R., Yousaf, Z., & Tehzeeb, K. (2021). Nutraceutical Intervention of Seeds in the Treatment of Poly Cystic Ovarian Syndrome; A Systematic Review: Nutraceutical Intervention; Seed Cycling. Pakistan BioMedical Journal, 4(2), 281-286.

Bae, J., Park, S., & Kwon, J. W. (2018). Factors associated with menstrual cycle irregularity and menopause. BMC women's health, 18(1), 1-11.

Bahrami, A., Ariakia, F., A Ferns, G., & Ghayour-Mobarhan, M. (2022). The Prevalence of Menstrual Problems amongst Adolescent Girls in Northeastern Iran. Journal of Advances in Medical and Biomedical Research, 30(138), 61-68.

Chitra, V., & Dhivya, D. P. (2017). Role of herbals in the management of polycystic ovarian syndrome and its associated symptoms. International Journal of Herbal Medicine, 5(5), 125-31.

De Sanctis, V., Bernasconi, S., Bianchin, L., Bona, G., Bozzola, M., Buzi, F., ... & Perissinotto, E. (2014). The onset of menstrual cycle and menses features among secondary school girls in Italy: A questionnaire study on 3,783 students. Indian Journal of Endocrinology and Metabolism, 18(Suppl 1), S84.

Dotto, J. M., & Chacha, J. S. (2020). The potential of pumpkin seeds as a functional food ingredient: A review. Scientific African, 10, e00575.

Dowidar, M., Ahmed, A., & Mohamed, H. (2020). The critical nutraceutical role of pumpkin seeds in human and animal health: An updated review. Zagazig Veterinary Journal, 48(2), 199-212.

Ebrahimi, B., Nazmara, Z., Hassanzadeh, N., Yarahmadi, A., Ghaffari, N., Hassani, F., ... & Hassanzadeh, G. (2021). Biomedical features of flaxseed against different pathologic situations: A narrative review. Iranian Journal of Basic Medical Sciences, 24(5), 551.

Emam, S. R., Abd-Elsalam, R. M., Azouz, A. A., Ali, S. E., El Badawy, S. A., Ibrahim, M. A., ... & Elmosalamy, S. H. (2021). Linum usitatissimum seeds oil down-regulates mRNA expression for the steroidogenic acute regulatory protein and Cyp11A1 genes, ameliorating letrozole-induced polycystic ovarian syndrome in a rat model. Journal of Physiological and Pharmacology, 72(1).

Farzana, F. K., Sulaiman, A., Ruckmani, A., Vijayalakshmi, K., Lakshmi. K. G., Ranjini, S. S., & Duraivel, M. (2015). Effects of Flax Seeds Supplementation in Polycystic Ovarian Syndrome. International Journal of Pharmaceutical Sciences Review and Research, 31(1), 113-119.

Guan, Y. S., & He, Q. (2015). Plants consumption and liver health. Evidence-Based Complementary and Alternative Medicine.

Gulzar, S., Khan, S., Abbas, K., Arif, S., Husain, S. S., Imran, H., & Sommer, J. (2015). Prevalence, perceptions, and effects of dysmenorrhea in school-going female adolescents of Karachi, Pakistan. International Journal of Innovative Research and Development, 4(2), 235-40.

Haidari, F., Banaei-Jahromi, N., Zakerkish, M., & Ahmadi, K. (2020). The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial. Nutrition journal, 19, 1-11.

Hawkins, S.M. & Matzuk, M. M. (2008). The menstrual cycle: basic biology. Annals of the New York Academy of Sciences, 1135(1), 10-18.

Irfan, T., Seher, K., Rizwan, B., Fatima, S., & Sani, A. (2021). Role of Seed Cycling in Polycystic Ovarian Syndrome: Seed Cycling in PCOS. Pakistan BioMedical Journal, 4(2), 21-25.

Jacob, J., Vijayakumar, N., & Olickal, J. J. (2021). Effect of satapushpa churnam with tilatailam in oligomenorrhea associated with polycystic ovarian syndrome. Journal of Ayurveda and Integrative Medicine, 12(4), 695-699.

Jahromi, S. M., & Jahromi, S. N. (2020). The effect of hydro-alcoholic extract of pumpkin seeds on estrogen levels and kidney markers in adult female rats. Iranian Red Crescent Medical Journal, 22(4).

Jelodar, G., Masoomi, S., & Rahmanifar, F. (2018). Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iranian Journal of Basic Medical Sciences, 21(6), 645.

Joshi, A., Muthal, A., Namdeo, A., & Shinde, V. (2023). Integrative approaches for the management of PCOS: A review. International Journal of Herbal Medicine,11(2), 18-32.

Khanage, S. G., Subhash, T. Y., & Bhaiyyasaheb, I. R. (2019). Herbal drugs for the treatment of Polycystic ovary syndrome (PCOS) and its complications. Pharmaceutical Research, 2(1), 5-13.

Kispotta, A., Prince, L., & Thomas, S. (2022). An Experimental study to assess the effectiveness of Flax Seed Supplement for reducing PCOD symptoms among females of reproductive age group in Namkum, Ranchi, Jharkhand. International Journal of Advances in Nursing Management, 10(4), 379-384.

Ko, K. M., Han, K., Chung, Y. J., Yoon, K. H., Park, Y. G., & Lee, S. H. (2017). Association between body weight changes and menstrual irregularity: the Korea National Health and Nutrition Examination Survey 2010 to 2012. Endocrinology and Metabolism, 32(2), 248-256.

Kwan, B. S., Kim, S. C., Jo, H. C., Baek, J. C., & Park, J. E. (2022). The Association between Menstrual Irregularities and the Risk of Diabetes in Premenopausal and Postmenopausal Women: A Cross-Sectional Study of a Nationally Representative Sample. In Healthcare, 18(1), 649.

Mahapatra, D., Baro, J., & Das, M. (2023). Advantages of seed cycling diet in menstrual dysfunctions: A review-based explanation. The Pharma Innovation Journal, 12(4), 931-939.

Manouchehri, A., Abbaszadeh, S., Ahmadi, M., Nejad, F. K., Bahmani, M., & Dastyar, N. (2023). Polycystic ovaries and herbal remedies: A systematic review. JBRA assisted reproduction, 27(1), 85.

Mansoor S, Haque A, Rani A. (2021). Flaxseed: a promising alternative for polycystic ovarian syndrome therapy. Journal of Health Science and Medicine, 4(4): 524-525.

Matar, S. S., Farrag, A. A., Hafez, S. M., & Fahmy, R. M. (2021). The Bioactive Effect of Flaxseed on Women with the Polycystic Ovarian Syndrome. Egyptian Journal of Nutrition, 36(3), 49-77.

Mehraban, M., Jelodar, G., & Rahmanifar, F. (2020). A combination of spearmint and flaxseed extract improved the endocrine and histomorphology of the ovary in experimental PCOS. Journal of Ovarian Research, 13(1).

Mirmasoumi, G., Fazilati, M., Foroozanfard, F., Vahedpoor, Z., Mahmoodi, S., Taghizadeh, M., ... & Asemi, Z. (2017). The effects of flaxseed oil omega-3 fatty acids supplementation on metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology & Diabetes, 126(04), 222-228.

Najafi, M. N., Kasaian, J., Kovatsi, L., Leon, G., Solout, E. K., Hashemzaei, M., ... & Ghazanfarpour, M. (2018). Phytoestrogens and the polycystic ovary syndrome: a systematic review of clinical evidence and laboratory findings. Farmacia, 66(2), 223-229.

Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007). Polycystic ovary syndrome. The Lancet, 370(9588), 685-697.

Osman, N. N., Alsahfi, S. A., & Alshubaily, F. (2019). Effectiveness of aqueous extract of fenugreek seeds and flaxseed on polycystic ovarian syndrome in female rats. International Journal of Pharmaceutical Research&Allied Sciences, 8(4), 42-54.

Rasheed, N., Ahmed, A., Nosheen, F., Imran, A., Islam, F., Noreen, R., ... & Amer Ali, Y. (2023). Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females. Food Science & Nutrition.

Rizvi, Q. H., Sharma, V., Shams, R., Dar, A. H., Jan, B., & Manzoor, A. (2021). Extraction of oil from flaxseed using three-phase partitioning. Journal of Postharvest Technology, 9(1), 35-45.

Syed, Q. A., Akram, M., & Shukat, R. (2019). Nutritional and therapeutic importance of the pumpkin seeds. Seed, 21(2), 15798-15803.

Thakur, N. S., & Singh, S. P. (2022). Nutritional quality of beetroot and multi seeds for chips. Magnesium (mg), 23, 2-0.

Thiyagarajan, D. K. (2021). Physiology, menstrual cycle. In StatPearls.

Tian, X., Diaz, F.J., (2012). Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice. Endocrinology, 153(2), 873-86.

Vaziri, F., Zamani Lari, M., Samsami Dehaghani, A., Salehi, M., Sadeghpour, H., Akbarzadeh, M., & Zare, N. (2014). Comparing the effects of dietary flaxseed and omega-3 Fatty acids supplement on cyclical mastalgia in Iranian women: a randomized clinical trial. International Journal of Family Medicine.

Wang, T., Sha, L., Li, Y., Zhu, L., Wang, Z., Li, K., ... & Wang, H. (2020). Dietary α-Linolenic acid-rich flaxseed oil exerts beneficial effects on polycystic ovary syndrome through sex steroid hormones—microbiota—inflammation axis in rats. Frontiers in endocrinology, 11, 284.

Yavari, M., Rouholamin, S., Tansaz, M., Bioos, S., & Esmaeili, S. (2014). Sesame a treatment of menstrual bleeding cessation in Iranian traditional medicine: Results from a pilot study. Shiraz E-Medical Journal, 15(3).

Zafar, U., Memon, Z., Moin, K., Agha, S., Hassan, J. A., & Zehra, D. (2019). Prevalence of PCOS with associated symptoms and complications at tertiary care hospital of Karachi. Journal of Advances in Medicine and Medical Research, 30(4), 1-9.

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Published

2024-05-27

How to Cite

Evaluation of Effect of Seed Cycling on Menstrual Irregularity Among Women. (2024). Pakistan Journal of Allied Health Sciences, 2(2), 38-55. http://pjahs.com/index.php/pjahs/article/view/16